解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.790
更新日期:2012-10-01 00:00:00
abstract::Severe hemorrhage following a prostatectomy is a rare and serious complication. A 63-year-old male with severe hemorrhage following radical prostatectomy which led to hypovolemic shock presented at our department and was treated with superselective internal iliac arterial embolization. At 6 months follow-up, the patie...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.749
更新日期:2012-09-01 00:00:00
abstract::Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.766
更新日期:2012-09-01 00:00:00
abstract::Epithelial ovarian cancer has the highest mortality of all gynecological cancers, and its progression is often without symptoms. Clinical outcome and survival may be improved if the disease is identified in the early stages. The objective of the study was to evaluate the utility of the serum biomarkers human epididymi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.757
更新日期:2012-09-01 00:00:00
abstract::Ganglioneuromas (GNs) arising from neural crest sympathogonia are rare benign neurogenic tumors. The most commonly affected sites are the posterior mediastinum, the retroperitoneum and the adrenal gland. GNs often present as a solitary, painless and slow-growing mass, and multiple occurrences in the cervical region ar...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.767
更新日期:2012-09-01 00:00:00
abstract::Dermatofibrosarcoma protuberans (DFSP) is a relatively rare low-grade sarcoma that occasionally exhibits melanin-containing spindle cells within the tumor. Fibrosarcomatous DFSP (FS-DFSP) is a variant that is characterized by areas which are histopathologically indistinguishable from fibrosarcoma. In the present study...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.765
更新日期:2012-09-01 00:00:00
abstract::The aims of this study were to determine the methylation and expression status of secreted Frizzled-related protein 1 (SFRP1) in bladder cancer, to explore the mechanisms involved and to study the role of SFRP1 in the pathogenesis of bladder cancer. SFRP1 mRNA was detected by reverse transcription PCR (RT-PCR). The DN...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.713
更新日期:2012-08-01 00:00:00
abstract::Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.710
更新日期:2012-08-01 00:00:00
abstract::KG-1 and its less differentiated subline KG-1a are leukemia cell lines used in research in a number of laboratories. The karyotypes of the two lines were initially identical. In the following years, further analysis revealed that the cell lines had acquired additional karyotypical abnormalities and differed in the pre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.709
更新日期:2012-08-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as a global chromatin organizer to regulate gene expression. Recent studies have suggested an oncogenic role of SATB1 in breast cancer. However, the role of SATB1 in gastric cancer, especially in regulating the malignant phenotypes, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.681
更新日期:2012-07-01 00:00:00
abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.687
更新日期:2012-07-01 00:00:00
abstract::Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.701
更新日期:2012-07-01 00:00:00
abstract::The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The searc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.690
更新日期:2012-07-01 00:00:00
abstract::A 56-year-old male patient with locally advanced mucinous rectal cancer underwent neoadjuvant chemoradiotherapy. Follow-up imaging with positron emission tomography-computed tomography (PET-CT) revealed a local response to chemoradiotherapy, whereas diffusion-weighted magnetic resonance imaging (DW-MRI) showed newly p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.663
更新日期:2012-06-01 00:00:00
abstract::The clinical use of doxorubicin (DOX), a potent antineoplastic agent, is limited by its serious side-effects, which include acute and chronic cumulative dose-related cardiotoxicity. Berberine (BER), a botanical alkaloid, has been reported to possess cardioprotective and antitumor effects. The 3-(4,5-dimethyl-2-thiazol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.644
更新日期:2012-06-01 00:00:00
abstract::In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.641
更新日期:2012-06-01 00:00:00
abstract::The prognosis following surgical treatment of gastric carcinoma (GC) or gastroesophageal junction (GEJ) adenocarcinoma remains poor. Although adjuvant chemo-radiotherapy with 5-fluorouracil has been shown to be beneficial, a high rate of distant failure has been reported. Thus, the toxicity profile and efficacy of an ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.617
更新日期:2012-05-01 00:00:00
abstract::Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the featur...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.622
更新日期:2012-05-01 00:00:00
abstract::FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.603
更新日期:2012-05-01 00:00:00
abstract::The purpose of this study was to present the results of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC), and to clarify patient characteristics by investigating patient background factors. A total of 59 patients with EC, who received MPA as fertility-sparing therapy a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.602
更新日期:2012-05-01 00:00:00
abstract::The purpose of this study was to evaluate the cytotoxic effect of thalidomide on 4T1 and 4THMpc mouse breast cancer cell lines. Mouse breast cancer cells (4T1) and cells derived from metastatic lesions (4THMpc) were treated with various doses of thalidomide [10(-2)-100 µM dissolved in dimethyl sulfoxide (DMSO) as reco...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.559
更新日期:2012-04-01 00:00:00
abstract::Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 singl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.581
更新日期:2012-04-01 00:00:00
abstract::[-2]pro-prostate-specific antigen (2pPSA), a proform of PSA, is a new marker in patients at risk of prostate cancer. We explored the potential role of 2pPSA in the identification of patients with metastatic progression following radical prostatectomy for prostate cancer. Seventy-six patients with biochemical (PSA) rec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.570
更新日期:2012-04-01 00:00:00
abstract::No evidence currently exists to demonstrate the prognostic value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with unresectable colorectal cancer liver metastases (CRLM). Therefore, we retrospectively investigated the correlation between serum CEA and CA19-9 levels and ove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.574
更新日期:2012-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) contributes to 14.8% of all cancer mortality in Egypt, which has a high prevalence of hepatitis C virus (HCV). We have previously shown alterations in the insulin-like growth factor-1 (IGF-1) receptor signalling pathway during experimental hepatocarcinogenesis. The aim of this study was ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.546
更新日期:2012-03-01 00:00:00
abstract::The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The result...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.527
更新日期:2012-03-01 00:00:00
abstract::Recent studies have shown that a small subpopulation of stem-like cancer cells within most solid tumors are responsible for the malignancy of aggressive cancer cells, including tumorigenicity and relapse of solid tumors. These tumor cells may be enriched and maintained in vitro in the presence of growth factors (GFs),...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.531
更新日期:2012-03-01 00:00:00
abstract::Extraosseous osteosarcoma originating from paratesticular soft tissue is an extremely rare type of malignant tumor. With the exception of the present study, only one other case of osteosarcoma originating from paratesticular soft tissue has previously been reported. A 52-year-old man presented with a painless scrotal ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.518
更新日期:2012-03-01 00:00:00
abstract::DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.522
更新日期:2012-03-01 00:00:00
abstract::The DNA methyltransferase 3A (DNMT3A) -448A>G polymorphism is a novel functional single nucleotide polymorphism (SNP) that contributes to the genetic susceptibility to gastric cancer. In this study, we aimed to assess the genotype frequencies of DNMT3A -448A>G in colorectal cancer (CRC) patients and healthy control su...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.488
更新日期:2012-02-01 00:00:00
abstract::Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.471
更新日期:2012-02-01 00:00:00
abstract::The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.497
更新日期:2012-02-01 00:00:00
abstract::The purpose of this study was to confirm the correlation between serum levels of cystatin C (Cys-C) and those of creatinine (Cre), the most widely used index of renal function in clinical practice, and to evaluate serum levels of Cys-C, with a particular focus on the effects of aging, body mass index (BMI), C-reactive...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.377
更新日期:2012-02-01 00:00:00
abstract::Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, manifests as a papulonodular lesion in the oral mucosa and has been associated with the human papillomavirus, a virus related to various precancerous diseases in the oral cavity. It has a predisposition for the female gender and for children. Altho...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.465
更新日期:2012-02-01 00:00:00
abstract::In previous studies, we observed that STAT1 and Survivin correlated negatively with gastric cancer tissues, and that the functions of the IFN-γ-STAT1 pathway and Survivin in gastric cancer are the same as those reported for other types of cancer. In this study, the SGC7901 gastric cancer cell line and 83 gastric cance...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.423
更新日期:2012-01-01 00:00:00
abstract::Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.425
更新日期:2012-01-01 00:00:00
abstract::Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.427
更新日期:2012-01-01 00:00:00
abstract::Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uter...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.428
更新日期:2012-01-01 00:00:00
abstract::The majority of giant cell tumors (GCTs) occur in the ends of the long bones. The presence of more than one GCT in the axial skeleton is rare. A GCT is capable of remaining clinically latent following treatment and becoming active a number of years later. We report an extremely rare case of GCT occurring in the axial ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.402
更新日期:2011-11-01 00:00:00
abstract::The molecular profile of low-grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low-grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP-2, MMP-7 and MMP-9 was detected by immunohistochemistry in a coho...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_2011.387
更新日期:2011-11-01 00:00:00